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What happens when a person with some edited genetics (like say, eagle eyes) reproduces with a person with regular genetics?


Evolution of species with separate sapient and non-sapient forms?What are the evolutionary benefits of mating for life, as opposed to serial monogamy?What happens when cut with a heated blade?Could a person see with glowing eyes?What would people with black eyes see?Post apocalyptic science based storyWhat happens when two flames meet from opposite sides?






.everyoneloves__top-leaderboard:empty,.everyoneloves__mid-leaderboard:empty,.everyoneloves__bot-mid-leaderboard:empty margin-bottom:0;








5












$begingroup$


If person A has had the genes dictating their sight/ the internal structure of their eyes, replaced by say, eagle eyes or cat eyes.



What happens when they reproduce with person B who has regular human genetics?



I would imagine that the genes governing eye structure in cats are incompatible with the genes governing eye structure in humans.



Would the offspring of A and B just not have eyes? Or would their eyes not form properly? Or would they maybe have one set of genes dominate the other and act as a single source of information for the formation of their eyes?



Essentially my question is what happens when two humans/animals that share the majority of their genetics (enough to count as the same species) but have key differences in certain sets of genes mate together?










share|improve this question









$endgroup$









  • 1




    $begingroup$
    If you want a nicer, less awful, a somewhat more predictable result keep your edits to a single gene, or even a single codon if possible.
    $endgroup$
    – kleer001
    Aug 16 at 22:44










  • $begingroup$
    That's genetic condition treatment in a nutshell.
    $endgroup$
    – ThisRandomGuy
    Aug 17 at 18:11

















5












$begingroup$


If person A has had the genes dictating their sight/ the internal structure of their eyes, replaced by say, eagle eyes or cat eyes.



What happens when they reproduce with person B who has regular human genetics?



I would imagine that the genes governing eye structure in cats are incompatible with the genes governing eye structure in humans.



Would the offspring of A and B just not have eyes? Or would their eyes not form properly? Or would they maybe have one set of genes dominate the other and act as a single source of information for the formation of their eyes?



Essentially my question is what happens when two humans/animals that share the majority of their genetics (enough to count as the same species) but have key differences in certain sets of genes mate together?










share|improve this question









$endgroup$









  • 1




    $begingroup$
    If you want a nicer, less awful, a somewhat more predictable result keep your edits to a single gene, or even a single codon if possible.
    $endgroup$
    – kleer001
    Aug 16 at 22:44










  • $begingroup$
    That's genetic condition treatment in a nutshell.
    $endgroup$
    – ThisRandomGuy
    Aug 17 at 18:11













5












5








5





$begingroup$


If person A has had the genes dictating their sight/ the internal structure of their eyes, replaced by say, eagle eyes or cat eyes.



What happens when they reproduce with person B who has regular human genetics?



I would imagine that the genes governing eye structure in cats are incompatible with the genes governing eye structure in humans.



Would the offspring of A and B just not have eyes? Or would their eyes not form properly? Or would they maybe have one set of genes dominate the other and act as a single source of information for the formation of their eyes?



Essentially my question is what happens when two humans/animals that share the majority of their genetics (enough to count as the same species) but have key differences in certain sets of genes mate together?










share|improve this question









$endgroup$




If person A has had the genes dictating their sight/ the internal structure of their eyes, replaced by say, eagle eyes or cat eyes.



What happens when they reproduce with person B who has regular human genetics?



I would imagine that the genes governing eye structure in cats are incompatible with the genes governing eye structure in humans.



Would the offspring of A and B just not have eyes? Or would their eyes not form properly? Or would they maybe have one set of genes dominate the other and act as a single source of information for the formation of their eyes?



Essentially my question is what happens when two humans/animals that share the majority of their genetics (enough to count as the same species) but have key differences in certain sets of genes mate together?







science-based biology science genetics genetic-engineering






share|improve this question













share|improve this question











share|improve this question




share|improve this question










asked Aug 16 at 22:05









HeliosHelios

261 bronze badge




261 bronze badge










  • 1




    $begingroup$
    If you want a nicer, less awful, a somewhat more predictable result keep your edits to a single gene, or even a single codon if possible.
    $endgroup$
    – kleer001
    Aug 16 at 22:44










  • $begingroup$
    That's genetic condition treatment in a nutshell.
    $endgroup$
    – ThisRandomGuy
    Aug 17 at 18:11












  • 1




    $begingroup$
    If you want a nicer, less awful, a somewhat more predictable result keep your edits to a single gene, or even a single codon if possible.
    $endgroup$
    – kleer001
    Aug 16 at 22:44










  • $begingroup$
    That's genetic condition treatment in a nutshell.
    $endgroup$
    – ThisRandomGuy
    Aug 17 at 18:11







1




1




$begingroup$
If you want a nicer, less awful, a somewhat more predictable result keep your edits to a single gene, or even a single codon if possible.
$endgroup$
– kleer001
Aug 16 at 22:44




$begingroup$
If you want a nicer, less awful, a somewhat more predictable result keep your edits to a single gene, or even a single codon if possible.
$endgroup$
– kleer001
Aug 16 at 22:44












$begingroup$
That's genetic condition treatment in a nutshell.
$endgroup$
– ThisRandomGuy
Aug 17 at 18:11




$begingroup$
That's genetic condition treatment in a nutshell.
$endgroup$
– ThisRandomGuy
Aug 17 at 18:11










2 Answers
2






active

oldest

votes


















8













$begingroup$

There are three generals outcomes given your set of circumstances.



Outcome #1: The genes are incompatible - for whatever reason, the two genes work against each other, maybe they inhibit each other's expression, or they don't synchronize properly. In your case, you wind up with blind offspring.



Outcome #2: One gene is dominant over the other. Normal genetics take over. This is more likely to occur when you're working with altered human genetics than transposed cat genetics. In your scenario, whichever set of genes is dominant (super eyes or normal eyes) gets expressed.



Outcome #3: Co-dominance / Incomplete dominance. These are two different things entirely, either both genes are fully expressed or one gene is partially expressed, resulting in a hybrid. I lumped them together because they result in the same outcome, a hybrid. Such a hybrid, for instance, might be better-than-average eyes, or even better-than-eagle-eyes, somehow. It would not be one normal eye and one super eye.



As for what happens in your scenario, the inserted Eagle Eyes DNA would probably clash with human DNA, and the offspring would be blind entirely. Thanks to recombination and crossing over, their children would also keep passing along traces of eagle DNA, and result in a family with eye defects.






share|improve this answer









$endgroup$














  • $begingroup$
    TL;DR: technology most likely would not pass tests on mouses.
    $endgroup$
    – val
    Aug 17 at 9:20






  • 1




    $begingroup$
    Regarding your last paragraph, the eyes of all vertebrates are all homologous, and the genes governing their formation are pretty much the same. The differences are mostly in when, where and how much those genes are expressed during fetal development, i.e. quantitative. Thus, my guess would be that if you randomly mixed up the relevant eye development genes from, say, humans and eagles, you'd probably still get eyes. Maybe not very good eyes — the resulting hybrid individual might well end up being "legally blind" — but probably with at least some limited capability for vision.
    $endgroup$
    – Ilmari Karonen
    Aug 17 at 10:01


















7













$begingroup$

Somatic mutations are not heritable.



If you want your gene edits heritable then you will need to edit the germline of the entire organism. Your edited gene parent and normal gene parent will both contribute genes to the offspring and the offspring of the phenotype will depend on dose and dominance of the edited and wild type genes it inherits.



Or a cleaner way would be to produce somatic mutants. Genetically modify only the cells of the eye. The germ cells of your edited organism remain wild type and any children will not be affected by somatic mutations in one of the parents. An example using current tech would be if I get a bone marrow transplant from my sister when I am 11. My blood cells will be female - her blood cells. Over time some of these blood cells might take up residence in various organs. But my sperm are original issue and not female sperm cells, and any children I might beget are unaffected by the fact that I have blood cells with DNA not my own.



A nice thing about this is that you cannot steal my genetic engineering prowess and breed your own creatures carrying my edited genes which I worked hard on. Genetic modifications from my lab are not heritable and die when my modified individual dies. If you like the modifications I make and want some for your individual, hire me. Or coerce me to do what you want, if you are sure you will never be turning your back on my creations.






share|improve this answer









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    2 Answers
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    2 Answers
    2






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    active

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    active

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    8













    $begingroup$

    There are three generals outcomes given your set of circumstances.



    Outcome #1: The genes are incompatible - for whatever reason, the two genes work against each other, maybe they inhibit each other's expression, or they don't synchronize properly. In your case, you wind up with blind offspring.



    Outcome #2: One gene is dominant over the other. Normal genetics take over. This is more likely to occur when you're working with altered human genetics than transposed cat genetics. In your scenario, whichever set of genes is dominant (super eyes or normal eyes) gets expressed.



    Outcome #3: Co-dominance / Incomplete dominance. These are two different things entirely, either both genes are fully expressed or one gene is partially expressed, resulting in a hybrid. I lumped them together because they result in the same outcome, a hybrid. Such a hybrid, for instance, might be better-than-average eyes, or even better-than-eagle-eyes, somehow. It would not be one normal eye and one super eye.



    As for what happens in your scenario, the inserted Eagle Eyes DNA would probably clash with human DNA, and the offspring would be blind entirely. Thanks to recombination and crossing over, their children would also keep passing along traces of eagle DNA, and result in a family with eye defects.






    share|improve this answer









    $endgroup$














    • $begingroup$
      TL;DR: technology most likely would not pass tests on mouses.
      $endgroup$
      – val
      Aug 17 at 9:20






    • 1




      $begingroup$
      Regarding your last paragraph, the eyes of all vertebrates are all homologous, and the genes governing their formation are pretty much the same. The differences are mostly in when, where and how much those genes are expressed during fetal development, i.e. quantitative. Thus, my guess would be that if you randomly mixed up the relevant eye development genes from, say, humans and eagles, you'd probably still get eyes. Maybe not very good eyes — the resulting hybrid individual might well end up being "legally blind" — but probably with at least some limited capability for vision.
      $endgroup$
      – Ilmari Karonen
      Aug 17 at 10:01















    8













    $begingroup$

    There are three generals outcomes given your set of circumstances.



    Outcome #1: The genes are incompatible - for whatever reason, the two genes work against each other, maybe they inhibit each other's expression, or they don't synchronize properly. In your case, you wind up with blind offspring.



    Outcome #2: One gene is dominant over the other. Normal genetics take over. This is more likely to occur when you're working with altered human genetics than transposed cat genetics. In your scenario, whichever set of genes is dominant (super eyes or normal eyes) gets expressed.



    Outcome #3: Co-dominance / Incomplete dominance. These are two different things entirely, either both genes are fully expressed or one gene is partially expressed, resulting in a hybrid. I lumped them together because they result in the same outcome, a hybrid. Such a hybrid, for instance, might be better-than-average eyes, or even better-than-eagle-eyes, somehow. It would not be one normal eye and one super eye.



    As for what happens in your scenario, the inserted Eagle Eyes DNA would probably clash with human DNA, and the offspring would be blind entirely. Thanks to recombination and crossing over, their children would also keep passing along traces of eagle DNA, and result in a family with eye defects.






    share|improve this answer









    $endgroup$














    • $begingroup$
      TL;DR: technology most likely would not pass tests on mouses.
      $endgroup$
      – val
      Aug 17 at 9:20






    • 1




      $begingroup$
      Regarding your last paragraph, the eyes of all vertebrates are all homologous, and the genes governing their formation are pretty much the same. The differences are mostly in when, where and how much those genes are expressed during fetal development, i.e. quantitative. Thus, my guess would be that if you randomly mixed up the relevant eye development genes from, say, humans and eagles, you'd probably still get eyes. Maybe not very good eyes — the resulting hybrid individual might well end up being "legally blind" — but probably with at least some limited capability for vision.
      $endgroup$
      – Ilmari Karonen
      Aug 17 at 10:01













    8














    8










    8







    $begingroup$

    There are three generals outcomes given your set of circumstances.



    Outcome #1: The genes are incompatible - for whatever reason, the two genes work against each other, maybe they inhibit each other's expression, or they don't synchronize properly. In your case, you wind up with blind offspring.



    Outcome #2: One gene is dominant over the other. Normal genetics take over. This is more likely to occur when you're working with altered human genetics than transposed cat genetics. In your scenario, whichever set of genes is dominant (super eyes or normal eyes) gets expressed.



    Outcome #3: Co-dominance / Incomplete dominance. These are two different things entirely, either both genes are fully expressed or one gene is partially expressed, resulting in a hybrid. I lumped them together because they result in the same outcome, a hybrid. Such a hybrid, for instance, might be better-than-average eyes, or even better-than-eagle-eyes, somehow. It would not be one normal eye and one super eye.



    As for what happens in your scenario, the inserted Eagle Eyes DNA would probably clash with human DNA, and the offspring would be blind entirely. Thanks to recombination and crossing over, their children would also keep passing along traces of eagle DNA, and result in a family with eye defects.






    share|improve this answer









    $endgroup$



    There are three generals outcomes given your set of circumstances.



    Outcome #1: The genes are incompatible - for whatever reason, the two genes work against each other, maybe they inhibit each other's expression, or they don't synchronize properly. In your case, you wind up with blind offspring.



    Outcome #2: One gene is dominant over the other. Normal genetics take over. This is more likely to occur when you're working with altered human genetics than transposed cat genetics. In your scenario, whichever set of genes is dominant (super eyes or normal eyes) gets expressed.



    Outcome #3: Co-dominance / Incomplete dominance. These are two different things entirely, either both genes are fully expressed or one gene is partially expressed, resulting in a hybrid. I lumped them together because they result in the same outcome, a hybrid. Such a hybrid, for instance, might be better-than-average eyes, or even better-than-eagle-eyes, somehow. It would not be one normal eye and one super eye.



    As for what happens in your scenario, the inserted Eagle Eyes DNA would probably clash with human DNA, and the offspring would be blind entirely. Thanks to recombination and crossing over, their children would also keep passing along traces of eagle DNA, and result in a family with eye defects.







    share|improve this answer












    share|improve this answer



    share|improve this answer










    answered Aug 16 at 22:16









    HalfthawedHalfthawed

    5,7355 silver badges29 bronze badges




    5,7355 silver badges29 bronze badges














    • $begingroup$
      TL;DR: technology most likely would not pass tests on mouses.
      $endgroup$
      – val
      Aug 17 at 9:20






    • 1




      $begingroup$
      Regarding your last paragraph, the eyes of all vertebrates are all homologous, and the genes governing their formation are pretty much the same. The differences are mostly in when, where and how much those genes are expressed during fetal development, i.e. quantitative. Thus, my guess would be that if you randomly mixed up the relevant eye development genes from, say, humans and eagles, you'd probably still get eyes. Maybe not very good eyes — the resulting hybrid individual might well end up being "legally blind" — but probably with at least some limited capability for vision.
      $endgroup$
      – Ilmari Karonen
      Aug 17 at 10:01
















    • $begingroup$
      TL;DR: technology most likely would not pass tests on mouses.
      $endgroup$
      – val
      Aug 17 at 9:20






    • 1




      $begingroup$
      Regarding your last paragraph, the eyes of all vertebrates are all homologous, and the genes governing their formation are pretty much the same. The differences are mostly in when, where and how much those genes are expressed during fetal development, i.e. quantitative. Thus, my guess would be that if you randomly mixed up the relevant eye development genes from, say, humans and eagles, you'd probably still get eyes. Maybe not very good eyes — the resulting hybrid individual might well end up being "legally blind" — but probably with at least some limited capability for vision.
      $endgroup$
      – Ilmari Karonen
      Aug 17 at 10:01















    $begingroup$
    TL;DR: technology most likely would not pass tests on mouses.
    $endgroup$
    – val
    Aug 17 at 9:20




    $begingroup$
    TL;DR: technology most likely would not pass tests on mouses.
    $endgroup$
    – val
    Aug 17 at 9:20




    1




    1




    $begingroup$
    Regarding your last paragraph, the eyes of all vertebrates are all homologous, and the genes governing their formation are pretty much the same. The differences are mostly in when, where and how much those genes are expressed during fetal development, i.e. quantitative. Thus, my guess would be that if you randomly mixed up the relevant eye development genes from, say, humans and eagles, you'd probably still get eyes. Maybe not very good eyes — the resulting hybrid individual might well end up being "legally blind" — but probably with at least some limited capability for vision.
    $endgroup$
    – Ilmari Karonen
    Aug 17 at 10:01




    $begingroup$
    Regarding your last paragraph, the eyes of all vertebrates are all homologous, and the genes governing their formation are pretty much the same. The differences are mostly in when, where and how much those genes are expressed during fetal development, i.e. quantitative. Thus, my guess would be that if you randomly mixed up the relevant eye development genes from, say, humans and eagles, you'd probably still get eyes. Maybe not very good eyes — the resulting hybrid individual might well end up being "legally blind" — but probably with at least some limited capability for vision.
    $endgroup$
    – Ilmari Karonen
    Aug 17 at 10:01













    7













    $begingroup$

    Somatic mutations are not heritable.



    If you want your gene edits heritable then you will need to edit the germline of the entire organism. Your edited gene parent and normal gene parent will both contribute genes to the offspring and the offspring of the phenotype will depend on dose and dominance of the edited and wild type genes it inherits.



    Or a cleaner way would be to produce somatic mutants. Genetically modify only the cells of the eye. The germ cells of your edited organism remain wild type and any children will not be affected by somatic mutations in one of the parents. An example using current tech would be if I get a bone marrow transplant from my sister when I am 11. My blood cells will be female - her blood cells. Over time some of these blood cells might take up residence in various organs. But my sperm are original issue and not female sperm cells, and any children I might beget are unaffected by the fact that I have blood cells with DNA not my own.



    A nice thing about this is that you cannot steal my genetic engineering prowess and breed your own creatures carrying my edited genes which I worked hard on. Genetic modifications from my lab are not heritable and die when my modified individual dies. If you like the modifications I make and want some for your individual, hire me. Or coerce me to do what you want, if you are sure you will never be turning your back on my creations.






    share|improve this answer









    $endgroup$



















      7













      $begingroup$

      Somatic mutations are not heritable.



      If you want your gene edits heritable then you will need to edit the germline of the entire organism. Your edited gene parent and normal gene parent will both contribute genes to the offspring and the offspring of the phenotype will depend on dose and dominance of the edited and wild type genes it inherits.



      Or a cleaner way would be to produce somatic mutants. Genetically modify only the cells of the eye. The germ cells of your edited organism remain wild type and any children will not be affected by somatic mutations in one of the parents. An example using current tech would be if I get a bone marrow transplant from my sister when I am 11. My blood cells will be female - her blood cells. Over time some of these blood cells might take up residence in various organs. But my sperm are original issue and not female sperm cells, and any children I might beget are unaffected by the fact that I have blood cells with DNA not my own.



      A nice thing about this is that you cannot steal my genetic engineering prowess and breed your own creatures carrying my edited genes which I worked hard on. Genetic modifications from my lab are not heritable and die when my modified individual dies. If you like the modifications I make and want some for your individual, hire me. Or coerce me to do what you want, if you are sure you will never be turning your back on my creations.






      share|improve this answer









      $endgroup$

















        7














        7










        7







        $begingroup$

        Somatic mutations are not heritable.



        If you want your gene edits heritable then you will need to edit the germline of the entire organism. Your edited gene parent and normal gene parent will both contribute genes to the offspring and the offspring of the phenotype will depend on dose and dominance of the edited and wild type genes it inherits.



        Or a cleaner way would be to produce somatic mutants. Genetically modify only the cells of the eye. The germ cells of your edited organism remain wild type and any children will not be affected by somatic mutations in one of the parents. An example using current tech would be if I get a bone marrow transplant from my sister when I am 11. My blood cells will be female - her blood cells. Over time some of these blood cells might take up residence in various organs. But my sperm are original issue and not female sperm cells, and any children I might beget are unaffected by the fact that I have blood cells with DNA not my own.



        A nice thing about this is that you cannot steal my genetic engineering prowess and breed your own creatures carrying my edited genes which I worked hard on. Genetic modifications from my lab are not heritable and die when my modified individual dies. If you like the modifications I make and want some for your individual, hire me. Or coerce me to do what you want, if you are sure you will never be turning your back on my creations.






        share|improve this answer









        $endgroup$



        Somatic mutations are not heritable.



        If you want your gene edits heritable then you will need to edit the germline of the entire organism. Your edited gene parent and normal gene parent will both contribute genes to the offspring and the offspring of the phenotype will depend on dose and dominance of the edited and wild type genes it inherits.



        Or a cleaner way would be to produce somatic mutants. Genetically modify only the cells of the eye. The germ cells of your edited organism remain wild type and any children will not be affected by somatic mutations in one of the parents. An example using current tech would be if I get a bone marrow transplant from my sister when I am 11. My blood cells will be female - her blood cells. Over time some of these blood cells might take up residence in various organs. But my sperm are original issue and not female sperm cells, and any children I might beget are unaffected by the fact that I have blood cells with DNA not my own.



        A nice thing about this is that you cannot steal my genetic engineering prowess and breed your own creatures carrying my edited genes which I worked hard on. Genetic modifications from my lab are not heritable and die when my modified individual dies. If you like the modifications I make and want some for your individual, hire me. Or coerce me to do what you want, if you are sure you will never be turning your back on my creations.







        share|improve this answer












        share|improve this answer



        share|improve this answer










        answered Aug 16 at 23:18









        WillkWillk

        136k34 gold badges256 silver badges566 bronze badges




        136k34 gold badges256 silver badges566 bronze badges






























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