Formic acid IdentificationPharmacologyInteractionsReferencesClinical TrialsPharmacoeconomicsPropertiesSpectraTaxonomy
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Formic acid
Targets (50)Transporters (1)
Identification
- Name
- Formic acid
- Accession Number
- DB01942 (EXPT01461)
- Type
- Small Molecule
- Groups
- Experimental, Investigational
- Description
Formic acid (systematically called methanoic acid) is the simplest carboxylic acid. It is an important intermediate in chemical synthesis and occurs naturally, most famously in the venom of bee and ant stings. The principal use of formic acid is as a preservative and antibacterial agent in livestock feed.
- Structure
3D
Similar StructuresStructure for Formic acid (DB01942)
- Synonyms
- Acide formique
- Ameisensäure
- Aminic acid
- Bilorin
- Formic acid
- Formylic acid
- Hydrogen carboxylic acid
- Methanoic acid
- Acide formique
- External IDs
- E236 / FEMA NO. 2487
- Product Ingredients
Ingredient UNII CAS InChI Key Calcium formate NP3JD65NPY 544-17-2 CBOCVOKPQGJKKJ-UHFFFAOYSA-L - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Irospan 24/6
Calcium formate (155 mg/1) + Biotin (300 ug/1) + Biotin (300 ug/1) + Calcium Carbonate (100 mg/1) + Cyanocobalamin (10 ug/1) + Cyanocobalamin (10 ug/1) + Ferrous bisglycinate (65 mg/1) + Folic Acid (1 mg/1) + Folic Acid (1 mg/1) + Iron Dextran (65 mg/1) + Niacin (25 mg/1) + Niacin (25 mg/1) + Calcium pantothenate (300 ug/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Riboflavin sodium (5 mg/1) + Riboflavin (5 mg/1) + Sodium ascorbate (100 mg/1) + Sodium ascorbate (100 mg/1) + Succinic acid (150 mg/1) + Thiamine hydrochloride (5 mg/1) + Thiamine hydrochloride (5 mg/1)Kit WOMENS CHOICE PHARMACEUTICALS LLC 2011-04-15 Not applicable US 
NESTABS DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA
Calcium formate (155 mg/1) + Calcium Carbonate (45 mg/1) + Cholecalciferol (450 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (10 ug/1) + Doconexent (230 mg/1) + Ferrous bisglycinate (32 mg/1) + Folic Acid (1 mg/1) + Icosapent (30 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (100 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Sodium ascorbate (120 mg/1) + Thiamine mononitrate (3 mg/1) + Tocopherylquinone (30 [iU]/1) + Vitamin E (2 [iU]/1) + Zinc oxide (10 mg/1)Kit WOMENS CHOICE PHARMACEUTICALS LLC 2011-02-01 Not applicable US NESTABS Prenatal Multi-vitamin/Mineral Supplement
Calcium formate (155 mg/1) + Calcium Carbonate (45 mg/1) + Cholecalciferol (450 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (10 ug/1) + D-alpha-Tocopherol acetate (30 [iU]/1) + Ferrous bisglycinate (32 mg/1) + Folic Acid (1 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (100 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Sodium ascorbate (120 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (10 mg/1)Tablet, film coated Oral Womens Choice Pharmaceuticals, Llc 2011-02-01 Not applicable US Nutri-Tab OB
Calcium formate (155 mg/1) + Calcium Carbonate (45 mg/1) + Cholecalciferol (450 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (10 ug/1) + D-alpha-Tocopherol acetate (30 [iU]/1) + Ferrous bisglycinate (32 mg/1) + Folic Acid (1000 ug/1) + Nicotinamide (20 mg/1) + Potassium Iodide (100 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Sodium ascorbate (120 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (10 mg/1)Tablet Oral Wh Nutritionals, Llc 2012-05-03 Not applicable US Nutri-Tab OB plus DHA
Calcium formate (155 mg/1) + Calcium Carbonate (45 mg/1) + Cholecalciferol (450 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (10 ug/1) + D-alpha-Tocopherol acetate (30 [iU]/1) + Doconexent (230 mg/1) + Ferrous bisglycinate (32 mg/1) + Folic Acid (1000 ug/1) + Icosapent (30 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (100 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Sodium ascorbate (120 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (10 mg/1)Kit Wh Nutritionals, Llc 2012-05-03 Not applicable US Pre-Tabs DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA
Calcium formate (155 mg/1) + Calcium Carbonate (45 mg/1) + Cholecalciferol (450 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (10 ug/1) + Doconexent (230 mg/1) + Ferrous bisglycinate (32 mg/1) + Folic Acid (1 mg/1) + Icosapent (30 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (100 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Sodium ascorbate (120 mg/1) + Thiamine mononitrate (3 mg/1) + Tocofersolan (30 [iU]/1) + Vitamin E (2 [iU]/1) + Zinc oxide (10 mg/1)Kit DEREMETRX LLC 2014-06-15 Not applicable US Prenate DHA
Calcium formate (155 mg/1) + Ascorbic acid (90 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (25 ug/1) + DL-alpha-Tocopherol (40 [iU]/1) + Doconexent (300 mg/1) + Ferrous asparto glycinate (18 mg/1) + Folic Acid (1 mg/1) + Magnesium oxide (50 mg/1) + Pyridoxine hydrochloride (26 mg/1)Capsule, gelatin coated Oral Avion Pharmaceuticals, Llc 2014-06-05 Not applicable US Prenate Elite
Calcium formate (155 mg/1) + 5-methyltetrahydrofolic acid (600 ug/1) + Ascorbic acid (75 mg/1) + Beta carotene (2600 [iU]/1) + Biotin (330 ug/1) + Cholecalciferol (600 [iU]/1) + Cupric oxide (1.5 mg/1) + Cyanocobalamin (13 ug/1) + DL-alpha tocopheryl acetate (40 [iU]/1) + Ferrous asparto glycinate (20 mg/1) + Folic Acid (400 ug/1) + Magnesium oxide (25 mg/1) + Nicotinamide (21 mg/1) + Potassium Iodide (150 ug/1) + Pyridoxine hydrochloride (21 mg/1) + Riboflavin (3.5 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (15 mg/1)Tablet, coated Oral Avion Pharmaceuticals, Llc 2014-06-05 Not applicable US Prenate Essential
Calcium formate (155 mg/1) + 5-methyltetrahydrofolic acid (600 ug/1) + Ascorbic acid (90 mg/1) + Biotin (280 ug/1) + Cholecalciferol (220 [iU]/1) + Cyanocobalamin (13 ug/1) + DL-alpha tocopheryl acetate (10 [iU]/1) + Doconexent (300 mg/1) + Ferrous asparto glycinate (18 mg/1) + Folic Acid (400 ug/1) + Icosapent (40 mg/1) + Magnesium oxide (50 mg/1) + Potassium Iodide (150 ug/1) + Pyridoxine hydrochloride (26 mg/1)Capsule, gelatin coated Oral Avion Pharmaceuticals, Llc 2014-07-18 Not applicable US Prenate Star
Calcium formate (155 mg/1) + Ascorbic acid (75 mg/1) + Beta carotene (3300 [iU]/1) + Biotin (330 ug/1) + Cholecalciferol (450 [iU]/1) + Cupric oxide (1.5 mg/1) + Cyanocobalamin (12 ug/1) + Ferrous asparto glycinate (20 mg/1) + Folic Acid (1 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (21 mg/1) + Calcium pantothenate (6 mg/1) + Potassium Iodide (150 ug/1) + Pyridoxine hydrochloride (21 mg/1) + Riboflavin (2 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (15 mg/1)Tablet, coated Oral Avion Pharmaceuticals, Llc 2014-06-05 2018-01-31 US - Categories
- Acids, Acyclic
- Blood Coagulation Factors
- Hemostatics
- UNII
- 0YIW783RG1
- CAS number
- 64-18-6
- Weight
- Average: 46.0254
Monoisotopic: 46.005479308 - Chemical Formula
- CH2O2
- InChI Key
- BDAGIHXWWSANSR-UHFFFAOYSA-N
- InChI
- InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)
- IUPAC Name
- formic acid
- SMILES
- OC=O
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Pharmacology
- Indication
- Not Available
- Pharmacodynamics
- Not Available
- Mechanism of action
Target Actions Organism
UHeme oxygenase 1Not Available Humans
URibonuclease pancreaticNot Available Humans
UDihydroorotate dehydrogenase (quinone)Not Available Escherichia coli (strain K12)
U(S)-2-haloacid dehalogenaseNot Available Xanthobacter autotrophicus
UBeta-lactamase OXA-2Not Available Salmonella typhimurium
UCatalaseNot Available Proteus mirabilis
USignal recognition particle proteinNot Available Thermus aquaticus
UStreptavidinNot Available Streptomyces avidinii
UMethylglyoxal synthaseNot Available Shigella flexneri
UC-terminal-binding protein 1Not Available Humans
U6-phosphogluconolactonaseNot Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UCitrate lyase subunit beta-like proteinNot Available Mycobacterium tuberculosis
UPeripheral plasma membrane protein CASKNot Available Humans
UGuanylate kinaseNot Available Mycobacterium tuberculosis
UProbable butyrate kinase 2Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UGamma-glutamylaminecyclotransferaseNot Available Humans
UParvalbumin alphaNot Available Humans
UAcylphosphatase-2Not Available Humans
UUncharacterized proteinNot Available Bacillus cereus (strain ATCC 14579 / DSM 31)
UArginine N-succinyltransferase subunit alphaNot Available Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
UPutative mannose-6-phosphate isomerase YvyINot Available Bacillus subtilis (strain 168)
UNitric oxide synthase, brainNot Available Humans
UABC-type transporter, periplasmic subunitNot Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UProbable phosphatase YcdXNot Available Escherichia coli (strain K12)
UPhenazine biosynthesis protein PhzDNot Available Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
UOxalate decarboxylase OxdCNot Available Bacillus subtilis (strain 168)
UPutative ketoacyl reductaseNot Available Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
UGephyrinNot Available Humans
UGlyoxalase family proteinNot Available Bacillus cereus (strain ATCC 14579 / DSM 31)
UCytohesin-2Not Available Humans
UGlutaconyl-CoA decarboxylase subunit alphaNot Available Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / VR4)
UTranscriptional regulator, IclR familyNot Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UCatalaseNot Available Helicobacter pylori (strain ATCC 700392 / 26695)
UPutative L-rhamnose mutarotaseNot Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UGlutathione S-transferaseNot Available Plasmodium falciparum
UHypoxanthine-guanine phosphoribosyltransferaseNot Available Trypanosoma cruzi
UGlutaminase 1Not Available Bacillus subtilis (strain 168)
UGlutaminase 1Not Available Escherichia coli (strain K12)
UMolybdopterin synthase catalytic subunitNot Available Escherichia coli (strain K12)
UAminotransferase, putativeNot Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UIron binding protein FbpANot Available Pasteurella haemolytica
UDNA gyrase subunit BNot Available Thermus thermophilus
UPutative hydroxypyruvate isomerase YgbMNot Available Escherichia coli (strain K12)
UDelta-aminolevulinic acid dehydrataseNot Available Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
U3-phosphoshikimate 1-carboxyvinyltransferaseNot Available Escherichia coli (strain K12)
USubtilisin CarlsbergNot Available Bacillus licheniformis
UFibroblast growth factor 1Not Available Humans
UPeptide deformylaseNot Available Escherichia coli (strain K12)
UPara-aminobenzoate synthase component 1Not Available Escherichia coli (strain K12)
UCarbonic anhydrase 2Not Available Humans - Absorption
Formic acid is readily metabolized and eliminated by the body.
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half life
- Not Available
- Clearance
- Not Available
- Toxicity
ORAL (LD50): Acute: 700 mg/kg [Mouse]. 1100 mg/kg [Rat]. 4000 mg/kg [Dog].
- Affected organisms
- Not Available
- Pathways
Pathway Category Simvastatin Action Pathway Drug action Pravastatin Action Pathway Drug action Rosuvastatin Action Pathway Drug action Zoledronate Action Pathway Drug action Pamidronate Action Pathway Drug action Fluvastatin Action Pathway Drug action Lysosomal Acid Lipase Deficiency (Wolman Disease) Disease Hyperphenylalaniemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Disease Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Disease Cholesteryl Ester Storage Disease Disease Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Disease Folate Metabolism Metabolic Tryptophan Metabolism Metabolic Androgen and Estrogen Metabolism Metabolic Lovastatin Action Pathway Drug action Cerivastatin Action Pathway Drug action Hypercholesterolemia Disease Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) Disease Smith-Lemli-Opitz Syndrome (SLOS) Disease DOPA-Responsive Dystonia Disease Mevalonic Aciduria Disease Aromatase Deficiency Disease Pterine Biosynthesis Metabolic Steroid Biosynthesis Metabolic Ibandronate Action Pathway Drug action Alendronate Action Pathway Drug action Risedronate Action Pathway Drug action Atorvastatin Action Pathway Drug action 17-beta Hydroxysteroid Dehydrogenase III Deficiency Disease Desmosterolosis Disease - Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
Drug Interaction (R)-warfarin The therapeutic efficacy of Formic acid can be decreased when used in combination with (R)-warfarin. (S)-Warfarin The therapeutic efficacy of Formic acid can be decreased when used in combination with (S)-Warfarin. 4-hydroxycoumarin The therapeutic efficacy of Formic acid can be decreased when used in combination with 4-hydroxycoumarin. Abciximab The therapeutic efficacy of Formic acid can be decreased when used in combination with Abciximab. Acenocoumarol The therapeutic efficacy of Formic acid can be decreased when used in combination with Acenocoumarol. Acetylsalicylic acid The therapeutic efficacy of Formic acid can be decreased when used in combination with Acetylsalicylic acid. Alpha-1-proteinase inhibitor Alpha-1-proteinase inhibitor may increase the thrombogenic activities of Formic acid. Alteplase The therapeutic efficacy of Formic acid can be decreased when used in combination with Alteplase. Amediplase The therapeutic efficacy of Formic acid can be decreased when used in combination with Amediplase. Aminocaproic Acid The risk or severity of adverse effects can be increased when Aminocaproic Acid is combined with Formic acid. - Food Interactions
- Not Available
References
- Synthesis Reference
Gunter Roscher, Helmut Schaum, Heinz Schmitz, "Process for the preparation of practically formic acid-free acetic acid." U.S. Patent US4380663, issued August, 1944.
US4380663- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0000142
- KEGG Compound
- C00058
- PubChem Compound
- 284
- PubChem Substance
- 46508355
- ChemSpider
- 278
- ChEBI
- 30751
- ChEMBL
- CHEMBL116736
- PharmGKB
- PA449705
- HET
- FMT
- Wikipedia
- Formic_acid
- PDB Entries
1a5n / 1a5o / 1an5 / 1aob / 1aq6 / 1aus / 1axw / 1b93 / 1bdu / 1bid … show 1196 more- MSDS
Download (78.4 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 1 Completed Prevention Healthy Volunteers 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage forms
Form Route Strength Tablet, film coated Oral Tablet Oral Kit Capsule, gelatin coated Oral Tablet, coated Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Liquid
- Experimental Properties
Property Value Source melting point (°C) 8.3 °C PhysProp boiling point (°C) 101 °C PhysProp water solubility 1E+006 mg/L (at 25 °C) RIDDICK,JA ET AL. (1986) logP -0.54 HANSCH,C ET AL. (1995) pKa 3.75 (at 25 °C) RIDDICK,JA ET AL. (1986) - Predicted Properties
Property Value Source Water Solubility 477.0 mg/mL ALOGPS logP -0.47 ALOGPS logP -0.27 ChemAxon logS 1.02 ALOGPS pKa (Strongest Acidic) 4.27 ChemAxon Physiological Charge -1 ChemAxon Hydrogen Acceptor Count 2 ChemAxon Hydrogen Donor Count 1 ChemAxon Polar Surface Area 37.3 Å2 ChemAxon Rotatable Bond Count 0 ChemAxon Refractivity 8.15 m3·mol-1 ChemAxon Polarizability 3.37 Å3 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule Yes ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET features
Property Value Probability Human Intestinal Absorption + 0.9726 Blood Brain Barrier + 0.9652 Caco-2 permeable + 0.6096 P-glycoprotein substrate Non-substrate 0.8931 P-glycoprotein inhibitor I Non-inhibitor 0.9906 P-glycoprotein inhibitor II Non-inhibitor 0.9913 Renal organic cation transporter Non-inhibitor 0.9444 CYP450 2C9 substrate Non-substrate 0.8181 CYP450 2D6 substrate Non-substrate 0.9527 CYP450 3A4 substrate Non-substrate 0.8338 CYP450 1A2 substrate Non-inhibitor 0.9272 CYP450 2C9 inhibitor Non-inhibitor 0.9723 CYP450 2D6 inhibitor Non-inhibitor 0.9675 CYP450 2C19 inhibitor Non-inhibitor 0.9877 CYP450 3A4 inhibitor Non-inhibitor 0.9843 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9922 Ames test Non AMES toxic 0.9551 Carcinogenicity Carcinogens 0.6199 Biodegradation Ready biodegradable 0.9383 Rat acute toxicity 1.6531 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9799 hERG inhibition (predictor II) Non-inhibitor 0.9886
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)
Spectra
- Mass Spec (NIST)
Download (7.52 KB)- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Mass Spectrum (Electron Ionization) MS splash10-004j-9000000000-2e63b0c1e2e417b0d747 Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0002-9000000000-092f816e62c8d2f5d56e Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0002-9000000000-092f816e62c8d2f5d56e Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0002-9000000000-092f816e62c8d2f5d56e Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-9000000000-eb2207f7400e9144fff7 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-9000000000-eb2207f7400e9144fff7 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-9000000000-eb2207f7400e9144fff7 1H NMR Spectrum 1D NMR Not Applicable 13C NMR Spectrum 1D NMR Not Applicable 1H NMR Spectrum 1D NMR Not Applicable 13C NMR Spectrum 1D NMR Not Applicable 1H NMR Spectrum 1D NMR Not Applicable 13C NMR Spectrum 1D NMR Not Applicable [1H,1H] 2D NMR Spectrum 2D NMR Not Applicable [1H,13C] 2D NMR Spectrum 2D NMR Not Applicable
Taxonomy
- Description
- This compound belongs to the class of organic compounds known as carboxylic acids. These are compounds containing a carboxylic acid group with the formula -C(=O)OH.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Carboxylic acids and derivatives
- Sub Class
- Carboxylic acids
- Direct Parent
- Carboxylic acids
- Alternative Parents
- Monocarboxylic acids and derivatives / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Monocarboxylic acid or derivatives / Carboxylic acid / Organic oxygen compound / Organic oxide / Hydrocarbon derivative / Organooxygen compound / Carbonyl group / Aliphatic acyclic compound
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- monocarboxylic acid (CHEBI:30751) / Straight chain fatty acids, Saturated fatty acids (C00058)
Targets
Details1. Heme oxygenase 1
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Signal transducer activity
- Specific Function
- Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the a...
- Gene Name
- HMOX1
- Uniprot ID
- P09601
- Uniprot Name
- Heme oxygenase 1
- Molecular Weight
- 32818.345 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details2. Ribonuclease pancreatic
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Ribonuclease a activity
- Specific Function
- Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.
- Gene Name
- RNASE1
- Uniprot ID
- P07998
- Uniprot Name
- Ribonuclease pancreatic
- Molecular Weight
- 17644.125 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details3. Dihydroorotate dehydrogenase (quinone)
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Fmn binding
- Specific Function
- Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
- Gene Name
- pyrD
- Uniprot ID
- P0A7E1
- Uniprot Name
- Dihydroorotate dehydrogenase (quinone)
- Molecular Weight
- 36774.185 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details4. (S)-2-haloacid dehalogenase
- Kind
- Protein
- Organism
- Xanthobacter autotrophicus
- Pharmacological action
- Unknown
- General Function
- (s)-2-haloacid dehalogenase activity
- Specific Function
- Catalyzes the hydrolytic dehalogenation of small L-2-haloalkanoic acids to yield the corresponding D-2-hydroxyalkanoic acids. Active with 2-halogenated carboxylic acids and converts only the L-isom...
- Gene Name
- dhlB
- Uniprot ID
- Q60099
- Uniprot Name
- (S)-2-haloacid dehalogenase
- Molecular Weight
- 27469.15 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details5. Beta-lactamase OXA-2
- Kind
- Protein
- Organism
- Salmonella typhimurium
- Pharmacological action
- Unknown
- General Function
- Penicillin binding
- Specific Function
- This is an oxacillin-hydrolyzing beta-lactamase.
- Gene Name
- bla
- Uniprot ID
- P0A1V8
- Uniprot Name
- Beta-lactamase OXA-2
- Molecular Weight
- 31685.78 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details6. Catalase
- Kind
- Protein
- Organism
- Proteus mirabilis
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
- Gene Name
- katA
- Uniprot ID
- P42321
- Uniprot Name
- Catalase
- Molecular Weight
- 55614.085 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details7. Signal recognition particle protein
- Kind
- Protein
- Organism
- Thermus aquaticus
- Pharmacological action
- Unknown
- General Function
- Gtpase activity
- Specific Function
- Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the r...
- Gene Name
- ffh
- Uniprot ID
- O07347
- Uniprot Name
- Signal recognition particle protein
- Molecular Weight
- 47355.705 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details8. Streptavidin
- Kind
- Protein
- Organism
- Streptomyces avidinii
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
- Gene Name
- Not Available
- Uniprot ID
- P22629
- Uniprot Name
- Streptavidin
- Molecular Weight
- 18833.61 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details9. Methylglyoxal synthase
- Kind
- Protein
- Organism
- Shigella flexneri
- Pharmacological action
- Unknown
- General Function
- Methylglyoxal synthase activity
- Specific Function
- Not Available
- Gene Name
- mgsA
- Uniprot ID
- P0A733
- Uniprot Name
- Methylglyoxal synthase
- Molecular Weight
- 16918.435 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details10. C-terminal-binding protein 1
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Transcription factor binding
- Specific Function
- Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi...
- Gene Name
- CTBP1
- Uniprot ID
- Q13363
- Uniprot Name
- C-terminal-binding protein 1
- Molecular Weight
- 47534.865 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details11. 6-phosphogluconolactonase
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- 6-phosphogluconolactonase activity
- Specific Function
- Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
- Gene Name
- pgl
- Uniprot ID
- Q9X0N8
- Uniprot Name
- 6-phosphogluconolactonase
- Molecular Weight
- 25324.955 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details12. Citrate lyase subunit beta-like protein
- Kind
- Protein
- Organism
- Mycobacterium tuberculosis
- Pharmacological action
- Unknown
- General Function
- May play a role in fatty acid biosynthesis.
- Specific Function
- Lyase activity
- Gene Name
- citE
- Uniprot ID
- P9WPE1
- Uniprot Name
- Citrate lyase subunit beta-like protein
- Molecular Weight
- 28885.39 Da
Details13. Peripheral plasma membrane protein CASK
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Protein serine/threonine kinase activity
- Specific Function
- Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interact...
- Gene Name
- CASK
- Uniprot ID
- O14936
- Uniprot Name
- Peripheral plasma membrane protein CASK
- Molecular Weight
- 105121.915 Da
Details14. Guanylate kinase
- Kind
- Protein
- Organism
- Mycobacterium tuberculosis
- Pharmacological action
- Unknown
- General Function
- Essential for recycling GMP and indirectly, cGMP.
- Specific Function
- Adenylate kinase activity
- Gene Name
- gmk
- Uniprot ID
- P9WKE9
- Uniprot Name
- Guanylate kinase
- Molecular Weight
- 22095.065 Da
Details15. Probable butyrate kinase 2
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Butyrate kinase activity
- Specific Function
- Not Available
- Gene Name
- buk2
- Uniprot ID
- Q9X278
- Uniprot Name
- Probable butyrate kinase 2
- Molecular Weight
- 42022.04 Da
Details16. Gamma-glutamylaminecyclotransferase
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Gamma-glutamylcyclotransferase activity
- Specific Function
- Contributes to degradation of proteins cross-linked by transglutaminases. Degrades the cross-link between a lysine and a glutamic acid residue from two proteins that have been cross-linked by trans...
- Gene Name
- GGACT
- Uniprot ID
- Q9BVM4
- Uniprot Name
- Gamma-glutamylaminecyclotransferase
- Molecular Weight
- 17328.44 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details17. Parvalbumin alpha
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Calcium ion binding
- Specific Function
- In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.
- Gene Name
- PVALB
- Uniprot ID
- P20472
- Uniprot Name
- Parvalbumin alpha
- Molecular Weight
- 12058.635 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details18. Acylphosphatase-2
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Acylphosphatase activity
- Specific Function
- Its physiological role is not yet clear.
- Gene Name
- ACYP2
- Uniprot ID
- P14621
- Uniprot Name
- Acylphosphatase-2
- Molecular Weight
- 11139.52 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details19. Uncharacterized protein
- Kind
- Protein
- Organism
- Bacillus cereus (strain ATCC 14579 / DSM 31)
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q81C15
- Uniprot Name
- Uncharacterized protein
- Molecular Weight
- 12777.45 Da
Details20. Arginine N-succinyltransferase subunit alpha
- Kind
- Protein
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- Pharmacological action
- Unknown
- General Function
- Arginine n-succinyltransferase activity
- Specific Function
- Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine. Also acts on L-ornithine.
- Gene Name
- astA
- Uniprot ID
- P80357
- Uniprot Name
- Arginine N-succinyltransferase subunit alpha
- Molecular Weight
- 36930.335 Da
Details21. Putative mannose-6-phosphate isomerase YvyI
- Kind
- Protein
- Organism
- Bacillus subtilis (strain 168)
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Not Available
- Gene Name
- yvyI
- Uniprot ID
- P39841
- Uniprot Name
- Putative mannose-6-phosphate isomerase YvyI
- Molecular Weight
- 35427.725 Da
Details22. Nitric oxide synthase, brain
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Tetrahydrobiopterin binding
- Specific Function
- Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. P...
- Gene Name
- NOS1
- Uniprot ID
- P29475
- Uniprot Name
- Nitric oxide synthase, brain
- Molecular Weight
- 160969.095 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details23. ABC-type transporter, periplasmic subunit
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q9X0V0
- Uniprot Name
- Mannoside ABC transport system, sugar-binding protein
- Molecular Weight
- 64077.82 Da
Details24. Probable phosphatase YcdX
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Hydrolyzes p-nitrophenyl phosphate (pNPP) in vitro. Involved in the swarming motility process.
- Gene Name
- ycdX
- Uniprot ID
- P75914
- Uniprot Name
- Probable phosphatase YcdX
- Molecular Weight
- 26890.25 Da
Details25. Phenazine biosynthesis protein PhzD
- Kind
- Protein
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- Pharmacological action
- Unknown
- General Function
- Isochorismatase activity
- Specific Function
- Not Available
- Gene Name
- phzD1
- Uniprot ID
- Q7DC80
- Uniprot Name
- Phenazine biosynthesis protein PhzD
- Molecular Weight
- 23195.32 Da
Details26. Oxalate decarboxylase OxdC
- Kind
- Protein
- Organism
- Bacillus subtilis (strain 168)
- Pharmacological action
- Unknown
- General Function
- Oxalate decarboxylase activity
- Specific Function
- Converts oxalate to formate and CO(2) in an O(2)-dependent reaction. Can also catalyze minor side reactions: oxalate oxidation to produce H(2)O(2), and oxalate-dependent, H(2)O(2)-independent dye o...
- Gene Name
- oxdC
- Uniprot ID
- O34714
- Uniprot Name
- Oxalate decarboxylase OxdC
- Molecular Weight
- 43565.77 Da
Details27. Putative ketoacyl reductase
- Kind
- Protein
- Organism
- Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity
- Specific Function
- Not Available
- Gene Name
- actIII
- Uniprot ID
- P16544
- Uniprot Name
- Putative ketoacyl reductase
- Molecular Weight
- 27264.88 Da
Details28. Gephyrin
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Molybdopterin molybdotransferase activity
- Specific Function
- Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Ca...
- Gene Name
- GPHN
- Uniprot ID
- Q9NQX3
- Uniprot Name
- Gephyrin
- Molecular Weight
- 79747.635 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details29. Glyoxalase family protein
- Kind
- Protein
- Organism
- Bacillus cereus (strain ATCC 14579 / DSM 31)
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q81F54
- Uniprot Name
- Glyoxalase family protein
- Molecular Weight
- 16581.885 Da
Details30. Cytohesin-2
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Lipid binding
- Specific Function
- Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell...
- Gene Name
- CYTH2
- Uniprot ID
- Q99418
- Uniprot Name
- Cytohesin-2
- Molecular Weight
- 46545.725 Da
Details31. Glutaconyl-CoA decarboxylase subunit alpha
- Kind
- Protein
- Organism
- Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / VR4)
- Pharmacological action
- Unknown
- General Function
- Ligase activity
- Specific Function
- Decarboxylase subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD).
- Gene Name
- gcdA
- Uniprot ID
- Q06700
- Uniprot Name
- Glutaconyl-CoA decarboxylase subunit alpha
- Molecular Weight
- 64346.32 Da
Details32. Transcriptional regulator, IclR family
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Dna binding
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q9WXS0
- Uniprot Name
- Transcriptional regulator, IclR family
- Molecular Weight
- 28118.475 Da
Details33. Catalase
- Kind
- Protein
- Organism
- Helicobacter pylori (strain ATCC 700392 / 26695)
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
- Gene Name
- katA
- Uniprot ID
- P77872
- Uniprot Name
- Catalase
- Molecular Weight
- 58628.85 Da
Details34. Putative L-rhamnose mutarotase
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q9X0F9
- Uniprot Name
- Putative L-rhamnose mutarotase
- Molecular Weight
- 13061.115 Da
Details35. Glutathione S-transferase
- Kind
- Protein
- Organism
- Plasmodium falciparum
- Pharmacological action
- Unknown
- General Function
- Glutathione transferase activity
- Specific Function
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May also function as a storage protein or ligandin for parasitotoxic ferriprotoporphyrin I...
- Gene Name
- GST
- Uniprot ID
- Q8MU52
- Uniprot Name
- Glutathione S-transferase
- Molecular Weight
- 24788.9 Da
Details36. Hypoxanthine-guanine phosphoribosyltransferase
- Kind
- Protein
- Organism
- Trypanosoma cruzi
- Pharmacological action
- Unknown
- General Function
- Hypoxanthine phosphoribosyltransferase activity
- Specific Function
- Not Available
- Gene Name
- HGPRTase
- Uniprot ID
- Q27796
- Uniprot Name
- Hypoxanthine-guanine phosphoribosyltransferase
- Molecular Weight
- 25529.02 Da
Details37. Glutaminase 1
- Kind
- Protein
- Organism
- Bacillus subtilis (strain 168)
- Pharmacological action
- Unknown
- General Function
- Glutaminase activity
- Specific Function
- Not Available
- Gene Name
- glsA1
- Uniprot ID
- O31465
- Uniprot Name
- Glutaminase 1
- Molecular Weight
- 36186.3 Da
Details38. Glutaminase 1
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Glutaminase activity
- Specific Function
- Not Available
- Gene Name
- glsA1
- Uniprot ID
- P77454
- Uniprot Name
- Glutaminase 1
- Molecular Weight
- 32903.075 Da
Details39. Molybdopterin synthase catalytic subunit
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Molybdopterin synthase activity
- Specific Function
- Converts molybdopterin precursor Z to molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD.
- Gene Name
- moaE
- Uniprot ID
- P30749
- Uniprot Name
- Molybdopterin synthase catalytic subunit
- Molecular Weight
- 16980.955 Da
Details40. Aminotransferase, putative
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Transaminase activity
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q9X0L5
- Uniprot Name
- Aminotransferase, putative
- Molecular Weight
- 47135.19 Da
Details41. Iron binding protein FbpA
- Kind
- Protein
- Organism
- Pasteurella haemolytica
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Not Available
- Gene Name
- fbpA
- Uniprot ID
- Q9Z4N6
- Uniprot Name
- Iron ABC transporter substrate-binding protein
- Molecular Weight
- 38023.085 Da
Details42. DNA gyrase subunit B
- Kind
- Protein
- Organism
- Thermus thermophilus
- Pharmacological action
- Unknown
- General Function
- Dna topoisomerase type ii (atp-hydrolyzing) activity
- Specific Function
- Not Available
- Gene Name
- gyrB
- Uniprot ID
- Q5SHZ4
- Uniprot Name
- DNA gyrase subunit B
- Molecular Weight
- 70536.815 Da
Details43. Putative hydroxypyruvate isomerase YgbM
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Hydroxypyruvate isomerase activity
- Specific Function
- Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).
- Gene Name
- ygbM
- Uniprot ID
- Q46891
- Uniprot Name
- Putative hydroxypyruvate isomerase YgbM
- Molecular Weight
- 29216.725 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details44. Delta-aminolevulinic acid dehydratase
- Kind
- Protein
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen...
- Gene Name
- hemB
- Uniprot ID
- Q59643
- Uniprot Name
- Delta-aminolevulinic acid dehydratase
- Molecular Weight
- 37036.6 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details45. 3-phosphoshikimate 1-carboxyvinyltransferase
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- 3-phosphoshikimate 1-carboxyvinyltransferase activity
- Specific Function
- Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
- Gene Name
- aroA
- Uniprot ID
- P0A6D3
- Uniprot Name
- 3-phosphoshikimate 1-carboxyvinyltransferase
- Molecular Weight
- 46095.29 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details46. Subtilisin Carlsberg
- Kind
- Protein
- Organism
- Bacillus licheniformis
- Pharmacological action
- Unknown
- General Function
- Serine-type endopeptidase activity
- Specific Function
- Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides.
- Gene Name
- apr
- Uniprot ID
- P00780
- Uniprot Name
- Subtilisin Carlsberg
- Molecular Weight
- 38907.64 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details47. Fibroblast growth factor 1
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- S100 protein binding
- Specific Function
- Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
- Gene Name
- FGF1
- Uniprot ID
- P05230
- Uniprot Name
- Fibroblast growth factor 1
- Molecular Weight
- 17459.58 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details48. Peptide deformylase
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activi...
- Gene Name
- def
- Uniprot ID
- P0A6K3
- Uniprot Name
- Peptide deformylase
- Molecular Weight
- 19328.23 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details49. Para-aminobenzoate synthase component 1
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Oxo-acid-lyase activity
- Specific Function
- Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutami...
- Gene Name
- pabB
- Uniprot ID
- P05041
- Uniprot Name
- Aminodeoxychorismate synthase component 1
- Molecular Weight
- 50969.07 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details50. Carbonic anhydrase 2
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion in...
- Gene Name
- CA2
- Uniprot ID
- P00918
- Uniprot Name
- Carbonic anhydrase 2
- Molecular Weight
- 29245.895 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Transporters
Details1. Monocarboxylate transporter 4
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Symporter activity
- Specific Function
- Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine...
- Gene Name
- SLC16A3
- Uniprot ID
- O15427
- Uniprot Name
- Monocarboxylate transporter 4
- Molecular Weight
- 49468.9 Da
References
- Manning Fox JE, Meredith D, Halestrap AP: Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol. 2000 Dec 1;529 Pt 2:285-93. [PubMed:11101640]
Drug created on June 13, 2005 07:24 / Updated on March 08, 2019 19:35
